Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate | HCID 11544322 | — |
| Reactant | 914104-14-6 | HCID 54594949 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59239856 | HCID 59239856 | 75.8% |
Reaction Steps
A mixture of methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate (0.1 g), 1-[4-(2-aminoethyl)benzyl]pyrrolidin-2-one hydrochloride (87 mg), N,N-diisopropylethylamine (44 mg) and ethanol (2 ml) was stirred at 70° C. for 3 hr. The reaction mixture was allowed to cool, ethyl acetate was added, and the precipitate was collected by filtration to give the title compound (109 mg) as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07989445B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-59a8ab62a0e74fc79bd5fac9b58ed643 |
|---|
| Source note | uspto-grants-2011_08 |
|---|
