反应详情

温度

70 °C

A mixture of methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate (0.1 g), 1-[4-(2-aminoethyl)benzyl]pyrrolidin-2-one hydrochloride (87 mg), N,N-diisopropylethylamine (44 mg) and ethanol (2 ml) was stirred at 70° C. for 3 hr. The reaction mixture was allowed to cool, ethyl acetate was added, and the precipitate was collected by filtration to give the title compound (109 mg) as a colorless powder.

1. temperatureto cool
2. filtrationthe precipitate was collected by filtration