Hydrogen chloride-ethyl acetate → N-(4-{2-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]ethyl}benzyl)-N-methylglycine dihydrochloride

HRID 1668404Notes

Reaction equation

HRID 1668404 reaction equation
C([O:5][C:6](=[O:36])[CH2:7][N:8]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][N:19]2[C:24](=[O:25])[C:23]3[S:26][C:27]([C:29]4[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=4)=[CH:28][C:22]=3[N:21]=[CH:20]2)=[CH:13][CH:12]=1)[CH3:9])(C)(C)C.C(OCC)(=O)C.[ClH:43]>>[ClH:35].[ClH:43].[Cl:35][C:32]1[CH:33]=[CH:34][C:29]([C:27]2[S:26][C:23]3[C:24](=[O:25])[N:19]([CH2:18][CH2:17][C:14]4[CH:13]=[CH:12][C:11]([CH2:10][N:8]([CH3:9])[CH2:7][C:6]([OH:36])=[O:5])=[CH:16][CH:15]=4)[CH:20]=[N:21][C:22]=3[CH:28]=2)=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59239843N-(4-{2-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]ethyl}benzyl)-N-methylglycine tert-butyl ester

Product 1

HCID 67360373N-(4-{2-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]ethyl}benzyl)-N-methylglycine dihydrochloride

Procedure

A mixture of the compound (0.92 g) obtained in Example 29 and 4N hydrogen chloride-ethyl acetate solution was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (115 mg) as a colorless powder.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-3811f38ba5a349e38fe00beb93038e1f
Source dataset
uspto-grants-2011_08
Patent number
US07989445B2

Reaction notes

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