Hydrogen chloride-ethyl acetate → N-(4-{2-[6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]ethyl}benzyl)-N-methylglycine dihydrochloride

Participants

Reaction Steps

A mixture of the compound (0.92 g) obtained in Example 29 and 4N hydrogen chloride-ethyl acetate solution was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (115 mg) as a colorless powder.

Provenance & Evidence