反应详情

Product 11B is dissolved hemi-aminal in 10 mL anhydrous methanol and 100 mg 10-camphorsulfonic acid is added. Methanolysis is complete in 1 hour. The resulting material is filtered and concentrated, then reconstituted with ethyl acetate and washed with saturated bicarb followed by drying over anhydrous sodium sulfate, filtered and concentrated. LCMS characterization ES+383.1 (m+1).

1. additionis added
2. filtrationThe resulting material is filtered
3. concentrationconcentrated
4. washwashed with saturated bicarb
5. dry with materialby drying over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated