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HRID1668424

反应详情

EQUATION

反应方程式

HRID 1668424 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccccc1
HCID1140

Toluene

C7H8

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：C=CC[C@H]1CC[C@@H](C(=O)NCCc2ccccc2)N1C(=O)[C@H](CC=C)NC
HCID66995156

未命名化合物

PRODUCTS

生成物

1
结构：C=CC[C@H]1CC[C@@H](C(=O)NCCc2ccccc2)N1C(=O)[C@@H](N)CC=C
HCID57612851

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Product 11F is reconstituted in dichloromethane (40 mL) and added trifluoroacetic acid (10 mL). Stirring until reaction complete by HPLC. Toluene is added and concentrated to an amber oil. The product is dissolved in dichloromethane and washed with saturated bicarb followed by drying over anhydrous magnesium sulfate, filtering and concentrating to an amber solid. LCMS characterization ES+356.1 (m+1).

WORKUP

后处理

  1. concentrationconcentrated to an amber oil
  2. dissolutionThe product is dissolved in dichloromethane
  3. washwashed with saturated bicarb
  4. dry with materialby drying over anhydrous magnesium sulfate
  5. filtrationfiltering
  6. concentrationconcentrating to an amber solid