HCID 66995204, compound → HCID 15985678, compound

HRID 1668429Notes

Reaction equation

HRID 1668429 reaction equation
C(O[C:9](=O)[N:10]([C@H:12]([C:14](=[O:43])[NH:15][C:16]1[C:17](=[O:42])[N:18]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:30]=2)[C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:20][CH:21]=1)[CH3:13])C)C1C=CC=CC=1.[H][H]>C(O)C>[C:22]1([C:19]2[N:18]([CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([O:35][C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)[CH:30]=3)[C:17](=[O:42])[C:16]([NH:15][C:14](=[O:43])[C@@H:12]([NH:10][CH3:9])[CH3:13])=[CH:21][CH:20]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 66995204HCID 66995204, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15985678HCID 15985678, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 20D (55 mg, 0.094 mmol) in ethanol (2 mL) is hydrogenated under 10% palladium on carbon (10 mg) and hydrogen (balloon pressure). The reaction is monitored by LCMS. Upon completion the mixture is filtered and the filtrate is concentrated and purified by HPLC to afford the title compound (5 mg, 12%):

Workup

  1. filtrationUpon completion the mixture is filtered
  2. concentrationthe filtrate is concentrated
  3. custompurified by HPLC

Sources & evidence

ORD record
ord-7fa204221c0a4a7b8690558fc2c6e12f
Source dataset
uspto-grants-2011_08
Patent number
US07989441B2

Reaction notes

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