反应详情

1,1-Dimethylethyl 2-methyl-5,6,8,9-tetrahydro-7H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate (1.1 g) was exposed to trifluoroacetic acid (5 ml) in DCM (5 ml) for 90 min at 25° C. After elimination of volatiles under reduced pressure the residue was partitioned between aqueous Na2CO3 (2M) and DCM. The organic layer was collected and the aqueous phase extracted twice with DCM. The combined DCM layers were concentrated to give the title compound (0.84 g) as an off-white solid.

1. customAfter elimination of volatiles under reduced pressure the residue was partitioned between aqueous Na2CO3 (2M) and DCM
2. customThe organic layer was collected
3. extractionthe aqueous phase extracted twice with DCM
4. concentrationThe combined DCM layers were concentrated