HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Oxalyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Chlorobenzene | HCID 7964 | — |
| Reactant | 3,3,3-Trifluoropropionyl chloride | HCID 2783343 | — |
| Reactant | 1,1-Dimethylethyl 7-amino-8-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate | HCID 59150472 | — |
| Product | Oxalyl chloride | HCID 65578 | — |
| Product | 3,3,3-Trifluoropropionic acid | HCID 2777972 | — |
| Product | 2-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine | HCID 59150496 | — |
Reaction Steps
The title compound was prepared as described in General Procedure 2 from 1,1-dimethylethyl 7-amino-8-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate and 3,3,3-trifluoropropanoyl chloride. The latter reactant had been obtained in chlorobenzene solution from the reaction of 3,3,3-trifluoropropanoic acid with oxalyl chloride (1 eq.) in the presence of a catalytic quantity of DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989444B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-4394e2537b9c401f8d35b76812a2d200 |
| Source note | uspto-grants-2011_08 |