Sodium Carbonate → HCID 59150471, compound

HRID 1668576Notes

Reaction equation

HRID 1668576 reaction equation
[CH2:1]([C:3]1[C:22]2[C:6](=[CH:7][C:8]3[CH2:14][CH2:13][N:12](C(=O)C(F)(F)F)[CH2:11][CH2:10][C:9]=3[CH:21]=2)[O:5][N:4]=1)[CH3:2].C([O-])([O-])=O.[Na+].[Na+]>CO>[CH2:1]([C:3]1[C:22]2[C:6](=[CH:7][C:8]3[CH2:14][CH2:13][NH:12][CH2:11][CH2:10][C:9]=3[CH:21]=2)[O:5][N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 59150487HCID 59150487, compound

Product 1

HCID 59150471HCID 59150471, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Treatment of 3-ethyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine (21 mg) with Na2CO3 (1 mL, 1 M in water) in MeOH (2 mL) at reflux for 3 h followed by partitioning between water and dichloromethane and evaporation of the volatiles from the organic phase gave the title compound as a solidifying yellow oil in quantitative yield. The material was used as such without further characterisation.

Workup

  1. customby partitioning between water and dichloromethane and evaporation of the volatiles from the organic phase

Sources & evidence

ORD record
ord-269d4b6af08c4a79bbf600a8b8b83a4d
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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