Trifluoroacetic acid → HCID 59150528, compound

HRID 1668584Notes

Reaction equation

HRID 1668584 reaction equation
CC([C:5]1[C:18]2[N:19]=[C:20]([CH3:22])[S:21][C:17]=2[C:8]2[CH2:9][CH2:10][N:11](C([O-])=O)[CH2:12][CH2:13][C:7]=2[CH:6]=1)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:22][C:20]1[S:21][C:17]2[C:18]([N:19]=1)=[CH:5][C:6]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:7]=1[CH:8]=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86624112HCID 86624112, compound

Product 1

HCID 59150528HCID 59150528, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-dimethylethyl-2-methyl-6,7,9,10-tetrahydro-8H-[1,3]thiazolo[5,4-g][3]benzazepine-8-carboxylate (167 mg), was dissolved in DCM (5 ml) and added to TFA (2 ml). The mixture was stirred at rt. for 1 h and then concentrated affording a 2:1 mixture of title compound and its regioisomer (139 mg) that was further used as such.

Workup

  1. concentrationconcentrated
  2. customaffording

Sources & evidence

ORD record
ord-4e73e47fb7044c9db95825d478970cad
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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