5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 2-(1,1-Dimethylethyl)-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668606Notes

Reaction equation

HRID 1668606 reaction equation
[CH3:1][C:2]([C:5]1[O:6][C:7]2[C:17]([N:18]=1)=[CH:16][C:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15][C:9]=1[CH:8]=2)([CH3:4])[CH3:3].[Cl:19][CH2:20][CH2:21][CH2:22][S:23][C:24]1[N:25]([CH3:40])[C:26]([C:29]2[CH:38]=[CH:37][CH:36]=[C:35]3[C:30]=2[CH:31]=[CH:32][C:33]([CH3:39])=[N:34]3)=[N:27][N:28]=1>>[ClH:19].[CH3:4][C:2]([C:5]1[O:6][C:7]2[C:17]([N:18]=1)=[CH:16][C:10]1[CH2:11][CH2:12][N:13]([CH2:20][CH2:21][CH2:22][S:23][C:24]3[N:25]([CH3:40])[C:26]([C:29]4[CH:38]=[CH:37][CH:36]=[C:35]5[C:30]=4[CH:31]=[CH:32][C:33]([CH3:39])=[N:34]5)=[N:27][N:28]=3)[CH2:14][CH2:15][C:9]=1[CH:8]=2)([CH3:1])[CH3:3]

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 591504922-(1,1-Dimethylethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine

Product 1

HCID 673588032-(1,1-Dimethylethyl)-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-(1,1-dimethylethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.20 mmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a yellow slightly hygroscopic solid (59 μmmol).

Workup

  1. customwas obtained as a yellow slightly hygroscopic solid (59 μmmol)

Sources & evidence

ORD record
ord-b3c26f4be1d647578ca8bc25cbab3df3
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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