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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1668606Generated: November 2, 2026

5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 2-(1,1-Dimethylethyl)-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

https://huagongshe.com/reaction/1668606

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 25105050—
Reactant2-(1,1-Dimethylethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepineHCID 59150492—
Product2-(1,1-Dimethylethyl)-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochlorideHCID 67358803—

Reaction Steps

The title compound was prepared in analogy to General Procedure 1 from 2-(1,1-dimethylethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.20 mmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a yellow slightly hygroscopic solid (59 μmmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07989444B2
Source datasetuspto-grants-2011_08
ORD IDord-b3c26f4be1d647578ca8bc25cbab3df3
Source noteuspto-grants-2011_08