5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 7-(3-{[4-Methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-2-propyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668607Notes

Reaction equation

HRID 1668607 reaction equation
[CH2:1]([C:4]1[O:5][C:6]2[C:16]([N:17]=1)=[CH:15][C:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14][C:8]=1[CH:7]=2)[CH2:2][CH3:3].[Cl:18][CH2:19][CH2:20][CH2:21][S:22][C:23]1[N:24]([CH3:39])[C:25]([C:28]2[CH:37]=[CH:36][CH:35]=[C:34]3[C:29]=2[CH:30]=[CH:31][C:32]([CH3:38])=[N:33]3)=[N:26][N:27]=1>>[ClH:18].[CH3:39][N:24]1[C:25]([C:28]2[CH:37]=[CH:36][CH:35]=[C:34]3[C:29]=2[CH:30]=[CH:31][C:32]([CH3:38])=[N:33]3)=[N:26][N:27]=[C:23]1[S:22][CH2:21][CH2:20][CH2:19][N:12]1[CH2:11][CH2:10][C:9]2[CH:15]=[C:16]3[N:17]=[C:4]([CH2:1][CH2:2][CH3:3])[O:5][C:6]3=[CH:7][C:8]=2[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 591505032-Propyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine

Product 1

HCID 673579627-(3-{[4-Methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-2-propyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-propyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (87 μmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a colourless solid (55 μmol).

Sources & evidence

ORD record
ord-b021d0ffe14b408da20b2299463d97c5
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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