3-{5-[(3-Chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}pyridine → 2-Ethyl-7-(3-{[4-methyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668622Notes

Reaction equation

HRID 1668622 reaction equation
[CH2:1]([C:3]1[O:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2].[Cl:17][CH2:18][CH2:19][CH2:20][S:21][C:22]1[N:23]([CH3:33])[C:24]([C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[N:25][N:26]=1>>[ClH:17].[CH2:1]([C:3]1[O:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][N:11]([CH2:18][CH2:19][CH2:20][S:21][C:22]3[N:23]([CH3:33])[C:24]([C:27]4[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=4)=[N:25][N:26]=3)[CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2]

Participants

3

Reactant 2

HCID 534173103-{5-[(3-Chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}pyridineHCID 591504912-ethyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine

Product 1

HCID 673581912-Ethyl-7-(3-{[4-methyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-ethyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.25 mmol) and 3-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}pyridine and was obtained as a faint yellow slightly hygroscopic solid (0.12 mmol).

Sources & evidence

ORD record
ord-fe682273aba94b8f84aa9c95c6f0f5d0
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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