3-[(3-Chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole → 2-ethyl-7-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668630Notes

Reaction equation

HRID 1668630 reaction equation
[CH2:1]([C:3]1[S:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2].[Cl:17][CH2:18][CH2:19][CH2:20][S:21][C:22]1[N:26]([CH3:27])[C:25]([C:28]2[O:32][CH:31]=[N:30][C:29]=2[CH3:33])=[N:24][N:23]=1>>[ClH:17].[CH2:1]([C:3]1[S:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][N:11]([CH2:18][CH2:19][CH2:20][S:21][C:22]3[N:26]([CH3:27])[C:25]([C:28]4[O:32][CH:31]=[N:30][C:29]=4[CH3:33])=[N:24][N:23]=3)[CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2]

Participants

3

Reactant 2

HCID 446279943-[(3-Chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazoleHCID 591505142-ethyl-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine

Product 1

HCID 673581712-ethyl-7-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-ethyl-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine (0.14 mmol) and 3-[(3-chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole (0.16 mmol) and was obtained as a colourless slightly hygroscopic solid (13 mg).

Sources & evidence

ORD record
ord-8e5fddbc2bff4beca31203dd1a4cb350
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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