5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 2-(1-methylethyl)-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-3,5,6,7,8,9-hexahydroazepino[4,5-f]isoindol-1(2H)-one hydrochloride

HRID 1668643Notes

Reaction equation

HRID 1668643 reaction equation
[CH3:1][CH:2]([N:4]1[C:12](=[O:13])[C:11]2[CH:10]=[C:9]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18][C:8]3=[CH:7][C:6]=2[CH2:5]1)[CH3:3].[Cl:19][CH2:20][CH2:21][CH2:22][S:23][C:24]1[N:25]([CH3:40])[C:26]([C:29]2[CH:38]=[CH:37][CH:36]=[C:35]3[C:30]=2[CH:31]=[CH:32][C:33]([CH3:39])=[N:34]3)=[N:27][N:28]=1>>[ClH:19].[CH3:3][CH:2]([N:4]1[C:12](=[O:13])[C:11]2[CH:10]=[C:9]3[CH2:14][CH2:15][N:16]([CH2:20][CH2:21][CH2:22][S:23][C:24]4[N:25]([CH3:40])[C:26]([C:29]5[CH:38]=[CH:37][CH:36]=[C:35]6[C:30]=5[CH:31]=[CH:32][C:33]([CH3:39])=[N:34]6)=[N:27][N:28]=4)[CH2:17][CH2:18][C:8]3=[CH:7][C:6]=2[CH2:5]1)[CH3:1]

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 59150504HCID 59150504, compound

Product 1

HCID 673581262-(1-methylethyl)-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-3,5,6,7,8,9-hexahydroazepino[4,5-f]isoindol-1(2H)-one hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-(1-methylethyl)-3,5,6,7,8,9-hexahydroazepino[4,5-f]isoindol-1(2H)-one (80 mg) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline (130 mg) and was obtained as a colourless slightly hygroscopic solid (120 mg).

Sources & evidence

ORD record
ord-417183f17d7b4340856981822e073709
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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