Cesium carbonate → 1-(3-Bromophenyl)-1-(-(2-methoxy-ethoxy)-phenyl)-ethene

Participants

Reaction Steps

A mixture of 4-[1-(3-bromo-phenyl)-vinyl]-phenol (1.2 g, 4.0 mmol, 1 eq) N,N-dimethylformamide (10 mL), and cesium carbonate (2.8 g, 8.0 mmol, 2.0 eq) was stirred at room temperature then 1-bromo-2-methoxy-ethane (0.5 mL, 1.0 eq) was added. The mixture was heated to 50° C. overnight, cooled to room temperature and treated with water (100 mL). The reaction was extracted with dichloromethane, dried (sodium sulfate) and concentrated in vacuo. The crude was purified by flash chromatography eluting with cyclohexane to afford the title compound as a colorless oil (1.7 g, 85%);

Provenance & Evidence