反应详情

A mixture of 4-[1-(3-bromo-phenyl)-vinyl]-phenol (1.2 g, 4.0 mmol, 1 eq) N,N-dimethylformamide (10 mL), and cesium carbonate (2.8 g, 8.0 mmol, 2.0 eq) was stirred at room temperature then 1-bromo-2-methoxy-ethane (0.5 mL, 1.0 eq) was added. The mixture was heated to 50° C. overnight, cooled to room temperature and treated with water (100 mL). The reaction was extracted with dichloromethane, dried (sodium sulfate) and concentrated in vacuo. The crude was purified by flash chromatography eluting with cyclohexane to afford the title compound as a colorless oil (1.7 g, 85%);

1. temperatureThe mixture was heated to 50° C. overnight
2. temperaturecooled to room temperature
3. extractionThe reaction was extracted with dichloromethane
4. dry with materialdried (sodium sulfate)
5. concentrationconcentrated in vacuo
6. customThe crude was purified by flash chromatography
7. washeluting with cyclohexane