HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (RS)-4-(3-Bromo-phenyl)-4-(4-difluoromethoxy-3-methyl-phenyl)-4,5-dihydro-oxazol-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Acetonitrile ethyl acetate | HCID 21930812 | — |
| Reactant | 4-[1-(3-Bromophenyl)vinyl]-1-difluoromethoxy-2-methylbenzene | HCID 57825241 | — |
| Catalyst | HCID 178513473 | HCID 178513473 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (RS)-4-(3-Bromo-phenyl)-4-(4-difluoromethoxy-3-methyl-phenyl)-4,5-dihydro-oxazol-2-ylamine | HCID 57825083 | 85% |
Reaction Steps
According to general method 2, a solution of iodine in ethyl acetate was added to a mixture of 4-[1-(3-bromo-phenyl)-vinyl]-1-difluoromethoxy-2-methyl-benzene (4.9 g, 14 mmol) and silver cyanate in ethyl acetate/acetonitrile. The crude product of this reaction was subsequently reacted with aqueous ammonia (30% by vol). Purification by SCX yielded 4.8 g of product (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989449B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-65205eec9f204b059d549925e402a213 |
| Source note | uspto-grants-2011_08 |