反应详情

According to general method 2, a solution of iodine in ethyl acetate was added to a mixture of 4-[1-(3-bromo-phenyl)-vinyl]-1-difluoromethoxy-2-methyl-benzene (4.9 g, 14 mmol) and silver cyanate in ethyl acetate/acetonitrile. The crude product of this reaction was subsequently reacted with aqueous ammonia (30% by vol). Purification by SCX yielded 4.8 g of product (85%).

1. customPurification by SCX