HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57825072, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Acetonitrile ethyl acetate | HCID 21930812 | — |
| Reactant | 1-[1-(3-Bromophenyl)ethenyl]-4-(difluoromethoxy)-2-fluorobenzene | HCID 57825050 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57825072 | HCID 57825072 | — |
Reaction Steps
According to general method 2, a solution of iodine in ethyl acetate was added to a mixture of 4-[1-(3-bromo-phenyl)-vinyl]-1-difluoromethoxy-3-fluoro-benzene (4.9 g, 14 mmol) mid silver cyanate in ethyl acetate/acetonitrile. The crude product of this reaction was subsequently reacted with aqueous ammonia (30% by vol). Purification by SCX yield 2.0 g of product (35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989449B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0cac852f63484394a9730cf21819b1a0 |
| Source note | uspto-grants-2011_08 |