Ammonia → HCID 57825072, compound

HRID 1668727Notes

Reaction equation

HRID 1668727 reaction equation
II.[Br:3][C:4]1[CH:5]=[C:6]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH:19]([F:21])[F:20])=[CH:14][C:13]=2[F:22])=[CH2:11])[CH:7]=[CH:8][CH:9]=1.[NH3:23].C([O:27][CH2:28]C)(=O)C.C(#[N:32])C>C(OCC)(=O)C>[Br:3][C:4]1[CH:5]=[C:6]([C:10]2([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH:19]([F:20])[F:21])=[CH:14][C:13]=3[F:22])[CH2:11][O:27][C:28]([NH2:32])=[N:23]2)[CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 4

HCID 222AmmoniaHCID 807IodineHCID 21930812Acetonitrile ethyl acetateHCID 578250501-[1-(3-Bromophenyl)ethenyl]-4-(difluoromethoxy)-2-fluorobenzene

Product 1

HCID 57825072HCID 57825072, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

According to general method 2, a solution of iodine in ethyl acetate was added to a mixture of 4-[1-(3-bromo-phenyl)-vinyl]-1-difluoromethoxy-3-fluoro-benzene (4.9 g, 14 mmol) mid silver cyanate in ethyl acetate/acetonitrile. The crude product of this reaction was subsequently reacted with aqueous ammonia (30% by vol). Purification by SCX yield 2.0 g of product (35%).

Workup

  1. customPurification by SCX yield 2.0 g of product (35%)

Sources & evidence

ORD record
ord-0cac852f63484394a9730cf21819b1a0
Source dataset
uspto-grants-2011_08
Patent number
US07989449B2

Reaction notes

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