HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanol → 1180016-67-4
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | 3-Bromo-5-fluorobenzonitrile | HCID 2783330 | — |
| Product | 1180016-67-4 | HCID 57825204 | 77% |
Reaction Steps
In analogy to the procedure described in WO2007060448, the reaction of 3-bromo-5-fluorobenzonitrile with 2,2,2-trifluoro-ethanol using sodium bis(trimethylsilyl)amide as the base yielded the title compound as a white solid (yield: 77% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989449B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-691925d312114faba9a880c7d69b37a2 |
| Source note | uspto-grants-2011_08 |