2,2,2-Trifluoroethanol → 1180016-67-4

HRID 1668753Notes

Reaction equation

HRID 1668753 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8](F)[CH:9]=1)[C:5]#[N:6].[F:11][C:12]([F:16])([F:15])[CH2:13][OH:14].C[Si]([N-][Si](C)(C)C)(C)C.[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:14][CH2:13][C:12]([F:16])([F:15])[F:11])[CH:9]=1)[C:5]#[N:6]

Participants

4

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 2724254Sodium bis(trimethylsilyl)amideHCID 27833303-Bromo-5-fluorobenzonitrile

Product 1

HCID 578252041180016-67-4Yield 77%

Procedure

In analogy to the procedure described in WO2007060448, the reaction of 3-bromo-5-fluorobenzonitrile with 2,2,2-trifluoro-ethanol using sodium bis(trimethylsilyl)amide as the base yielded the title compound as a white solid (yield: 77% of theory).

Sources & evidence

ORD record
ord-691925d312114faba9a880c7d69b37a2
Source dataset
uspto-grants-2011_08
Patent number
US07989449B2

Reaction notes

Loading…