反应详情

In analogy to the procedure described in WO2007060448, the reaction of 3-bromo-5-fluorobenzonitrile with hydroxymethylcyclopropane using sodium bis(trimethylsilyl)amide as the base yielded the title compound as a white solid (yield: 84% of theory). TLC: Rf: 0.55 (silica gel:heptane:ethyl acetate=6:1, UV, 254 nm).