N-Methyl-4-anisidine → (2-Chloro-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine

HRID 1668779Notes

Reaction equation

HRID 1668779 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1.[CH3:16][O:17][C:18]1[CH:25]=[CH:24][C:21]([NH:22][CH3:23])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[N:11]=[C:10]([N:22]([C:21]2[CH:24]=[CH:25][C:18]([O:17][CH3:16])=[CH:19][CH:20]=2)[CH3:23])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 22250N-Methyl-4-anisidineHCID 127033662,4-Dichloro-6-nitroquinazoline

Product 1

HCID 11609884(2-Chloro-6-nitroquinazolin-4-yl)-(4-methoxyphenyl)-methylamine

Procedure

The title compound was prepared from 2,4-dichloro-6-nitro-quinazoline and 4-methoxy-N-methylaniline by a procedure similar to example 10. 1H NMR (CDCl3): 8.31 (dd, J=9.6, 3.6, 1H), 7.78 (d, J=9.3, 1H), 7.73 (d, J=2.4, 1H), 7.21 (m, 2H), 7.06 (m, 2H), 3.90 (s, 3H), 3.69 (s, 3H).

Sources & evidence

ORD record
ord-2b6036b36a004006804a9fd7752fd82a
Source dataset
uspto-grants-2011_08
Patent number
US07989462B2

Reaction notes

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