Sodium Hydroxide → HCID 59362928, compound

HRID 1668819Notes

Reaction equation

HRID 1668819 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18]3[C:23]4[CH2:24][CH2:25][CH2:26][C:22]=4[N:21]=[C:20]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)[N:19]=3)=[CH:13][CH:12]=2)[CH2:10][CH2:9][CH2:8]1)=[O:6]>O.CO>[N:27]1([C:20]2[N:19]=[C:18]([NH:17][C:14]3[CH:13]=[CH:12][C:11]([C:7]4([C:5]([OH:6])=[O:4])[CH2:10][CH2:9][CH2:8]4)=[CH:16][CH:15]=3)[C:23]3[CH2:24][CH2:25][CH2:26][C:22]=3[N:21]=2)[CH2:28][CH2:29][O:30][CH2:31][CH2:32]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 59362925HCID 59362925, compound

Product 1

HCID 59362928HCID 59362928, compoundYield 93.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of sodium hydroxide (0.588 g, 14.7 mmol) in water (15 mL) was added to a solution of 1-[4-(2-morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-phenyl]-cyclobutanecarboxylic acid methyl ester (1.0 g, 2.45 mmol) in MeOH (15 mL) and stirred at a temperature in the range of 15° C. to 40° C. for 3 hours. Thereafter, MeOH was evaporated under reduced pressure and pH of the solution was adjusted to ˜4 by adding concentrated hydrochloric acid. The precipitated solid was filtered, washed with water and dried in vacuo to afford the title compound as a white solid (0.9 g, 93.2% yield).

Workup

  1. customThereafter, MeOH was evaporated under reduced pressure and pH of the solution
  2. additionby adding concentrated hydrochloric acid
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-39327d70994f45418910e717481ac48f
Source dataset
uspto-grants-2011_08
Patent number
US07989463B2

Reaction notes

Loading…