Sodium Hydroxide → HCID 59362928, compound

Participants

Reaction Steps

A solution of sodium hydroxide (0.588 g, 14.7 mmol) in water (15 mL) was added to a solution of 1-[4-(2-morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-phenyl]-cyclobutanecarboxylic acid methyl ester (1.0 g, 2.45 mmol) in MeOH (15 mL) and stirred at a temperature in the range of 15° C. to 40° C. for 3 hours. Thereafter, MeOH was evaporated under reduced pressure and pH of the solution was adjusted to ˜4 by adding concentrated hydrochloric acid. The precipitated solid was filtered, washed with water and dried in vacuo to afford the title compound as a white solid (0.9 g, 93.2% yield).

Provenance & Evidence