反应详情

温度

180 °C

1-Chloro-6-methyl-5-nitroisoquinoline (0.25 g, 1.1 mmol) and 3-(trifluoromethyl)benzenamine (0.17 mL, 1.3 mmol) were added to a microwave tube containing 3 mL of isopropanol. The tube was capped and heated at 180° C. for 1500 seconds. The volatiles were removed in vacuo. The residue was taken up in DCM and washed with saturated NaHCO3. The organic layer was dried with sodium sulfate and purified by column chromatography on silica gel using a gradient of 10 to 40% of ethyl acetate in hexanes to give the product as an orange solid (0.31 g, 79%). MS (M+H)+ 348.

1. customThe tube was capped
2. customThe volatiles were removed in vacuo
3. washwashed with saturated NaHCO3
4. dry with materialThe organic layer was dried with sodium sulfate
5. custompurified by column chromatography on silica gel using a gradient of 10 to 40% of ethyl acetate in hexanes