huagongshe.com
HRID1668936

反应详情

EQUATION

反应方程式

HRID 1668936 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(P2(=S)SP(=S)(c3ccc(OC)cc3)S2)cc1
HCID87949

p-Anisyldithiophosphonic anhydride

C14H14O2P2S4

结构：CNc1ncc2cc(-c3c(C)ccc(C(=O)Nc4cccc(OC(C)C)c4)c3F)ccc2n1
HCID58829058

未命名化合物

PRODUCTS

生成物

1
结构：CNc1ncc2cc(-c3c(C)ccc(C(=S)Nc4cccc(OC(C)C)c4)c3F)ccc2n1
HCID58829668

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture of Lawesson's reagent (47 mg, 115 μmol) and 2-fluoro-N-(3-isopropoxyphenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide (93 mg, 209 μmol) in toluene (8 mL) was heated at reflux for 16 h. Solvent was removed in vacuo and the residue was purified by flash chromatography (25-70% EtOAc/hexane) to give the title compound. MS (M+H)+ 461.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. customSolvent was removed in vacuo
  4. customthe residue was purified by flash chromatography (25-70% EtOAc/hexane)