HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → HCID 58829668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 2-fluoro-N-(3-isopropoxyphenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide | HCID 58829058 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 58829668 | HCID 58829668 | — |
Reaction Steps
A mixture of Lawesson's reagent (47 mg, 115 μmol) and 2-fluoro-N-(3-isopropoxyphenyl)-4-methyl-3-(2-(methylamino)quinazolin-6-yl)benzamide (93 mg, 209 μmol) in toluene (8 mL) was heated at reflux for 16 h. Solvent was removed in vacuo and the residue was purified by flash chromatography (25-70% EtOAc/hexane) to give the title compound. MS (M+H)+ 461.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989461B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-f1a9115169444a1ea6ea1559d74dba30 |
| Source note | uspto-grants-2011_08 |