反应详情

1-(3-Aminopropyl)-3-pyrrolidinecarbonitrile (302) (0.36 g, 2.4 mmol) was added to a stirred solution of chloride 21 (402 mg, 1.8 mmol) and Et3N (0.76 mL, 5.4 mmol) in DME (50 mL) and the solution stirred at reflux temperature for 16 h. The solvent was evaporated and the residue partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL). The organic fraction was dried and the solvent evaporated. The residue was purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give 1-oxide 56 (476 mg, 78%) as a yellow solid: mp (EtOAc/pet. ether) 111-112° C.; 1H NMR δ 8.07 (s, 1H, H-9), 7.39 (s, 1H, H-5), 5.72 (br t, J=5.3 Hz, 1H, NH), 3.58 (q, J=6.4 Hz, 2H, CH2N), 2.95-3.07 (m, 6H, H-6, H-8, CH2N), 2.73-2.80 (m, 1H, CHCN), 2.55-2.68 (m, 4H, 2×CH2), 2.23-2.32 (m, 1H, CH2), 2.10-2.18 (m, 3H, CH2, H-7), 1.85 (p, J=6.7 Hz, 2H, CH2); 13C NMR δ 158.7, 154.6, 148.7, 143.3, 129.8, 122.1, 120.6, 114.6, 57.4, 53.3, 52.9, 40.2, 33.1, 32.3, 29.2, 27.7, 26.3, 25.7. Anal. calcd for C18H22N6O: C, 63.9; H, 6.6; N, 24.8. Found: C, 64.0; H, 6.4; N, 24.8%.

1. temperatureat reflux temperature for 16 h
2. customThe solvent was evaporated
3. customthe residue partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL)
4. customThe organic fraction was dried
5. customthe solvent evaporated
6. customThe residue was purified by chromatography
7. washeluting with a gradient (0-10%) of MeOH/DCM