反应详情

A solution of bis-(4-bromophenyl)methanone (406 mg, 1.19 mmol) in THF (12 mL) is cooled to 0° C., treated portion-wise with sodium borohydride (37.8 mg, 0.893 mmol), and stirred at RT overnight. The reaction mixture is again cooled to 0° C., then quenched with 1 N HCl. Water is added, and the mixture is extracted with ethyl acetate (3×). The combined organic layers are dried and concentrated to give bis-(4-bromophenyl)methanol (410 mg, in excess of theoretical yield) as a crude residue to be used as is.

1. temperatureThe reaction mixture is again cooled to 0° C.
2. customquenched with 1 N HCl
3. additionWater is added
4. extractionthe mixture is extracted with ethyl acetate (3×)
5. customThe combined organic layers are dried
6. concentrationconcentrated