Trimethyl phosphite → HCID 23131723, compound

HRID 1669365Notes

Reaction equation

Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7].[P:11]([O:16]C)([O:14][CH3:15])[O:12][CH3:13]>>[CH:6]([C:5]1[CH:4]=[C:3]([CH:10]=[CH:9][CH:8]=1)[CH2:2][P:11](=[O:16])([O:14][CH3:15])[O:12][CH3:13])=[O:7]

Participants

Reactant 2

HCID 8472Trimethyl phosphite

HCID 71278253-(Bromomethyl)benzaldehyde

Product 1

HCID 23131723HCID 23131723, compound

Conditions

Temperature: 100 °C

Procedure

A mixture of 0.60 g of 3-(bromomethyl)benzaldehyde and 0.45 ml of trimethyl phosphite was stirred at 100° C. for 3 hours. The reaction mixture was subjected to silica gel column chromatography to obtain 0.62 g of oily dimethyl (3-formylbenzyl)phosphonate [Compound No. (x)].

Sources & evidence

ORD record: ord-6eedd33a79c847ee95f986782927dec4
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989478B2

Reaction notes

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