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HRID1669398

反应详情

EQUATION

反应方程式

HRID 1669398 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：COC(CN(C)S(=O)(=O)NC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(C)CCNC(=O)OC(C)(C)C)COc1ccccc1-3)OC
HCID86627890

未命名化合物

PRODUCTS

生成物

1
结构：CN(CCN)[C@H]1COc2ccccc2-c2c(C3CCCCC3)c3ccc(C(=O)NS(=O)(=O)N(C)CC=O)cc3n2C1
HCID86627891

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
40 °C

PROCEDURE

实验过程

A solution of tert-butyl {2-[{(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)-(methyl)amino]sulfonyl}amino)carbonyl]-7,8-dihydro-6H-indolo[1,2-e][1,5]-benzoxazocin-7-yl}(methyl)amino]ethyl}carbamate (0.03 M) in DCM was treated with TFA (100 eq) and water (180 eq) at RT and the resulting mixture stirred vigorously for 3 h at 40° C. The volatiles were removed in vacuo and the residue diluted with Et2O and re-evaporated to drive off excess TFA. The product was used in the subsequent step without further purification. MS (ES+) m/z 582 (M+H)+; 600 (M+H2O+H)+.

WORKUP

后处理

  1. customThe volatiles were removed in vacuo
  2. additionthe residue diluted with Et2O
  3. customre-evaporated
  4. customThe product was used in the subsequent step without further purification