Hydrochloric Acid → (7R)-7-[{2-[(tert-butoxycarbonyl) (methyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To the solution of methyl (7R)-7-[{2-[(tert-butoxycarbonyl)(methyl)amino]-ethyl}(methyl)amino]-14-cyclohexyl-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate in dioxane (0.1 M) was added 2M KOH solution (3 eq). The mixture was warmed to 60° C. After 4 days the mixture was neutralised by addition of 1N HCl and all volatiles were evaporated in vacuo. The residual material was dried in vacuo and used without further purification. (ES+) m/z 669 (M+H)+.

Provenance & Evidence