HRID1669419

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14797

Potassium hydroxide

HKO

结构：COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(C)CCN(C)C(=O)OC(C)(C)C)COc1cc(OCc2ccccn2)ccc1-3

HCID67344554

未命名化合物

PRODUCTS

生成物

结构：CN(CCN(C)[C@H]1COc2cc(OCc3ccccn3)ccc2-c2c(C3CCCCC3)c3ccc(C(=O)O)cc3n2C1)C(=O)OC(C)(C)C

HCID67345446

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度: 60 °C

PROCEDURE

实验过程

To the solution of methyl (7R)-7-[{2-[(tert-butoxycarbonyl)(methyl)amino]-ethyl}(methyl)amino]-14-cyclohexyl-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate in dioxane (0.1 M) was added 2M KOH solution (3 eq). The mixture was warmed to 60° C. After 4 days the mixture was neutralised by addition of 1N HCl and all volatiles were evaporated in vacuo. The residual material was dried in vacuo and used without further purification. (ES+) m/z 669 (M+H)+.

WORKUP

后处理

customall volatiles were evaporated in vacuo
customThe residual material was dried in vacuo
customused without further purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-55ac0b830d9749958fd00b974f746353
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989438B2
来源说明: uspto-grants-2011_08

反应 SMILES

[C:1]([O:5][C:6]([N:8]([CH3:50])[CH2:9][CH2:10][N:11]([CH3:49])[C@@H:12]1[CH2:19][N:18]2[C:20]3[CH:21]=[C:22]([C:33]([O:35]C)=[O:34])[CH:23]=[CH:24][C:25]=3[C:26]([CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)=[C:17]2[C:16]2[CH:37]=[CH:38][C:39]([O:41][CH2:42][C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=3)=[CH:40][C:15]=2[O:14][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].Cl>O1CCOCC1>[C:1]([O:5][C:6]([N:8]([CH3:50])[CH2:9][CH2:10][N:11]([CH3:49])[C@@H:12]1[CH2:19][N:18]2[C:20]3[CH:21]=[C:22]([C:33]([OH:35])=[O:34])[CH:23]=[CH:24][C:25]=3[C:26]([CH:27]3[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]3)=[C:17]2[C:16]2[CH:37]=[CH:38][C:39]([O:41][CH2:42][C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=3)=[CH:40][C:15]=2[O:14][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]