HRID1669456

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：CN[C@H]1COc2ccccc2-c2c(C3CCCCC3)c3ccc(C(=O)OC)cc3n2C1

HCID66674181

未命名化合物

HCID131729078

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(C)CCN1CCC(N(C)C(=O)OC(C)(C)C)C1)COc1ccccc1-3

HCID67343719

未命名化合物

收率 64%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度: 140 °C

PROCEDURE

实验过程

A solution of methyl (7R)-14-cyclohexyl-7-(methylamino)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (1 eq) in MeCN was treated with tert-butyl[1-(2-chloroethyl)pyrrolidin-3-yl]methylcarbamate (2.4 eq) and NEt3 (2 eq) and heated at 140° C. in a microwave oven. The solvent was removed in vacuo and the residue purified by FC (Biotage; DCM/MeOH) to get the title compound as a white powder (64%). (ES+) m/z 645 (M+H)+.

WORKUP

后处理

customThe solvent was removed in vacuo
customthe residue purified by FC (Biotage; DCM/MeOH)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-62c4892ede2b462c8f373118502f95a6
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989438B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:28]([O:30][CH3:31])=[O:29])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[O:18][CH2:17][C@H:16]([NH:26][CH3:27])[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:32]([O:36][C:37](=[O:48])[NH:38][CH2:39]C1CCN(CCCl)C1)([CH3:35])([CH3:34])[CH3:33].[CH3:49][CH2:50][N:51]([CH2:54][CH3:55])[CH2:52][CH3:53]>CC#N>[C:32]([O:36][C:37]([N:38]([CH3:39])[CH:49]1[CH2:53][CH2:52][N:51]([CH2:54][CH2:55][N:26]([CH3:27])[C@@H:16]2[CH2:15][N:14]3[C:13]4[CH:12]=[C:11]([C:28]([O:30][CH3:31])=[O:29])[CH:10]=[CH:9][C:8]=4[C:7]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[C:21]3[C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[O:18][CH2:17]2)[CH2:50]1)=[O:48])([CH3:35])([CH3:34])[CH3:33]