HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → methyl (7R)-14-cyclohexyl-7-(methyl{2-[3-(methylamino)pyrrolidin-1-yl]ethyl}amino)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | methyl (7R)-7-[(2-{3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidin-1-yl}ethyl)(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate | HCID 67343719 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl (7R)-14-cyclohexyl-7-(methyl{2-[3-(methylamino)pyrrolidin-1-yl]ethyl}amino)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate | HCID 67343764 | — |
Reaction Steps
Methyl (7R)-7-[(2-{3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidin-1-yl}ethyl)(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate was dissolved in DCM and treated with TFA. The solution was stirred for 2 h at RT. The solvents were removed in vacuo to leave the product as pale yellow foam. (ES+) m/z 545 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989438B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-c630fa972dc047489b3abc10cc4b7a65 |
| Source note | uspto-grants-2011_08 |