HRID1669457

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：COC(=O)c1ccc2c(C3CCCCC3)c3n(c2c1)C[C@@H](N(C)CCN1CCC(N(C)C(=O)OC(C)(C)C)C1)COc1ccccc1-3

HCID67343719

未命名化合物

PRODUCTS

生成物

结构：CNC1CCN(CCN(C)[C@H]2COc3ccccc3-c3c(C4CCCCC4)c4ccc(C(=O)OC)cc4n3C2)C1

HCID67343764

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Methyl (7R)-7-[(2-{3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidin-1-yl}ethyl)(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate was dissolved in DCM and treated with TFA. The solution was stirred for 2 h at RT. The solvents were removed in vacuo to leave the product as pale yellow foam. (ES+) m/z 545 (M+H)+.

WORKUP

后处理

customThe solvents were removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c630fa972dc047489b3abc10cc4b7a65
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989438B2
来源说明: uspto-grants-2011_08

反应 SMILES

C(O[C:6]([N:8](C)[CH:9]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]([CH3:46])[C@@H:17]2[CH2:24][N:23]3[C:25]4[CH:26]=[C:27]([C:38]([O:40][CH3:41])=[O:39])[CH:28]=[CH:29][C:30]=4[C:31]([CH:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[C:22]3[C:21]3[CH:42]=[CH:43][CH:44]=[CH:45][C:20]=3[O:19][CH2:18]2)[CH2:10]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:32]1([C:31]2[C:30]3[CH:29]=[CH:28][C:27]([C:38]([O:40][CH3:41])=[O:39])=[CH:26][C:25]=3[N:23]3[C:22]=2[C:21]2[CH:42]=[CH:43][CH:44]=[CH:45][C:20]=2[O:19][CH2:18][C@H:17]([N:16]([CH3:46])[CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][CH:9]([NH:8][CH3:6])[CH2:10]2)[CH2:24]3)[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1