反应详情

温度

45 °C

A solution of N-(tert-butoxycarbonyl)-N,2-dimethylalanine in THF (0.17 M) was treated at RT with BH3-DMS complex in THF (10 eq., 2M) and the mixture was stirred at 45° C. for 8 h. The reaction was carefully quenched with H2O and the pH adjusted to 9 with 2M aq. Na2CO3. The mixture was then extracted with EtOAc and washed with brine. After drying over Na2SO4, the crude material was purified by FC (10-50% EtOAc in PE) to afford the product. (ES+) m/z 204 (M+H)+.

1. customThe reaction was carefully quenched with H2O
2. extractionThe mixture was then extracted with EtOAc
3. washwashed with brine
4. dry with materialAfter drying over Na2SO4
5. customthe crude material was purified by FC (10-50% EtOAc in PE)
6. customto afford the product