反应详情

2-(4-Fluoro-benzoylamino)-4-methoxy-3-methyl-benzoic acid (66) (830 mg, 2.7 mmol) was heated to 150° C. in formamide (20 ml) for 4 h. The excess formamide was removed by distillation. Water was added and the precipitated product was filtered of to give pure title compound (642 mg, 83%). MS (M+H+) 285.

1. customThe excess formamide was removed by distillation
2. additionWater was added
3. filtrationthe precipitated product was filtered of