Benzamide → HCID 178437757, compound

HRID 1669589Notes

Reaction equation

HRID 1669589 reaction equation
[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[C:14](N)(=O)[C:15]1C=CC=C[CH:16]=1.C(Cl)(=O)C>>[CH3:13][O:12][C:9]1[C:10]([CH3:11])=[C:2]2[C:3]([C:4]([OH:5])=[N:6][C:14]([CH2:15][CH3:16])=[N:1]2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 2331BenzamideHCID 6367Acetyl chlorideHCID 591654352-Amino-4-methoxy-3-methylbenzamide

Product 1

HCID 178437757HCID 178437757, compoundYield 100%

Procedure

The general procedure described in Example 31 was followed using 2-amino-4-methoxy-3-methyl benzamide as benzamide derivative [A] and acetic acid chloride as acid chloride [B], which gave the title compound (2.2 g, 100%). 1H-NMR DMSO-D6 δ 1.2 (m, 3H), 2.38 (s, 3H), 2.6 (m, 2H), 3.90 (s, 3H), 7.18 (d, 2H), 7.96 (d, 2H), 11.88 (s, 1H).

Sources & evidence

ORD record
ord-4ec9c1eab3d54b5e90f6c2fc3bc1f6d5
Source dataset
uspto-grants-2011_08
Patent number
US07989471B2

Reaction notes

Loading…