反应详情

(5S)-5-Methyl-5-({[4-[(trimethylsilyl)ethynyl]-3,6-dihydropyridin-1(2H) -yl]sulfonyl}methyl)imidazolidine-2,4-dione (2.27 g, 6.0 mmol) and potassium fluoride (1.07 g, 18.4 mmol) were stirred overnight at room temperature in methanol (50 mL). The solvent was evaporated off, the residue dissolved in EtOAc, washed with water followed by brine, dried (sodium sulphate) and evaporated. The residue was purified by column chromatography eluting with iso-hexane/EtOAc 1:1 to give a solid product (1.81 g).

1. customThe solvent was evaporated off
2. dissolutionthe residue dissolved in EtOAc
3. washwashed with water
4. dry with materialdried (sodium sulphate)
5. customevaporated
6. customThe residue was purified by column chromatography
7. washeluting with iso-hexane/EtOAc 1:1