HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 87365984, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1-carboxylate | HCID 10991161 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 87365984 | HCID 87365984 | 88% |
Reaction Steps
tert-Butyl 4-{[(trifluoromethyl)sulfonyl]oxy}-3,6-dihydropyridine-1(2H)-carboxylate (3.77 g, 11.4 mmol) was mixed with THF (15 mL) and concentrated hydrochloric acid (15 mL). After 1 hour, the mixture was evaporated and dried by azeotropic evaporation with toluene and methanol to give a beige solid (88%) that could be used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989620B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-1f7f19cf11374f31a1dc305a2ab9d8f4 |
| Source note | uspto-grants-2011_08 |