Hydrochloric Acid → HCID 87365984, compound

HRID 1669660Notes

Reaction equation

HRID 1669660 reaction equation
[F:1][C:2]([F:21])([F:20])[S:3]([O:6][C:7]1[CH2:8][CH2:9][N:10](C(OC(C)(C)C)=O)[CH2:11][CH:12]=1)(=[O:5])=[O:4].[ClH:22]>C1COCC1>[Cl-:22].[F:21][C:2]([F:1])([F:20])[S:3]([O:6][C:7]1[CH2:12][CH2:11][NH2+:10][CH2:9][CH:8]=1)(=[O:5])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10991161Tert-butyl 4-(trifluoromethanesulfonyloxy)-1,2,3,6-tetrahydropyridine-1-carboxylate

Product 1

HCID 87365984HCID 87365984, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

tert-Butyl 4-{[(trifluoromethyl)sulfonyl]oxy}-3,6-dihydropyridine-1(2H)-carboxylate (3.77 g, 11.4 mmol) was mixed with THF (15 mL) and concentrated hydrochloric acid (15 mL). After 1 hour, the mixture was evaporated and dried by azeotropic evaporation with toluene and methanol to give a beige solid (88%) that could be used without further purification.

Workup

  1. customthe mixture was evaporated
  2. dry with materialdried by azeotropic evaporation with toluene and methanol

Sources & evidence

ORD record
ord-1f7f19cf11374f31a1dc305a2ab9d8f4
Source dataset
uspto-grants-2011_08
Patent number
US07989620B2

Reaction notes

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