1,2-Bis(bromomethyl)-4-nitrobenzene → 4-Aminoindolin-2-one

HRID 1669683Notes

Reaction equation

HRID 1669683 reaction equation
BrCC1C=CC([N+]([O-])=O)=CC=1CBr.[N+:14]([C:17]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:18]=1[CH2:19][C:20](=[O:26])[NH:21]2)([O-])=O>>[NH2:14][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:18]=1[CH2:19][C:20](=[O:26])[NH:21]2

Participants

3

Reactant 2

HCID 108523601,2-Bis(bromomethyl)-4-nitrobenzeneHCID 216778744-Nitro-1,3-dihydro-2H-indol-2-one

Product 1

HCID 122374724-Aminoindolin-2-one

Procedure

Essentially following the procedures described in Intermediate 4, but using 4-nitro-1,3-dihydro-2H-indol-2-one from Step A in place of 5-nitro-1′-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one, the title compound was obtained. MS: m/z=149(M+1).

Sources & evidence

ORD record
ord-746564d338904342a9e423c0a12a77e6
Source dataset
uspto-grants-2011_08
Patent number
US07989624B2

Reaction notes

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