HCID 67334113, compound → HCID 44199384, compound

HRID 1669697Notes

Reaction equation

HRID 1669697 reaction equation
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[N+:17]([O-])=O)[N:8]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:13]([NH2:17])=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1

Participants

5

Reactant 2

HCID 67334113HCID 67334113, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 44199384HCID 44199384, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(2-Methoxy-benzyl)-(5-nitro-quinolin-2-yl)-amine (2.2 g, 7.1 mmol) was dissolved in 100 mL methanol. Palladium on charcoal (10%, 150 mg, 0.14 mmol) was added and the reaction mixture war hydrogenated with a hydrogen balloon overnight. The palladium was filtered off and the solvent was evaporated. The title compound was obtained as a yellow solid (1.98 g, 100%), MS: m/e=280.4 (M+H+).

Workup

  1. filtrationThe palladium was filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-88d3953fab994a00a4f826e2e56d8d9b
Source dataset
uspto-grants-2011_08
Patent number
US07989628B2

Reaction notes

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