反应详情

150 mg (0.52 mmol) of 3-[(5-fluoro-2-methyl-4-oxo-4H-chromen-8-yl)methylene]pentane-2,4-dione are dissolved with 40.4 mg (0.26 mmol) of cyclobutyl 3-aminocrotonate in 5 ml of 2-propanol and heated under reflux under argon for 3 h. The solvent is removed in vacuo, and the residue is purified by column chromatography (mobile phase: ethyl acetate/cyclohexane 2:1). 54.8 mg (50% of theory) of the title compound are obtained as a yellow solid.

1. temperatureheated
2. temperatureunder reflux under argon for 3 h
3. customThe solvent is removed in vacuo
4. customthe residue is purified by column chromatography (mobile phase: ethyl acetate/cyclohexane 2:1)